移植到裸鼠体内的内胚窦瘤合成的甲胎蛋白及其他血清蛋白

alpha-Fetoprotein and other serum proteins synthesized by endodermal sinus tumor transplanted into nude mice.

作者信息

Kaneko M, Takeuchi T, Tsuchida Y, Saito S, Endo Y

出版信息

Gan. 1980 Feb;71(1):14-7.

Abstract

The human yolk sac is said to synthesize not only alpha-fetoprotein but also other serum proteins, i.e., albumin, prealbumin, alpha 1-antitrypsin, and transferrin. Two endodermal sinus tumors (yolk sac tumors) were successfully transplanted into athymic nude mice. Concentration of these human serum proteins in the sera of the nude mice and tumor extracts was determined quantitatively by electro-immunodiffusion and radioimmunoassay. alpha-Fetoprotein and albumin were detected in one case, and alpha 1-antitrypsin and alpha-fetoprotein in the other. In the former case, the amount of alpha-fetoprotein synthesized was larger than that of albumin, whereas the amount of alpha-fetoprotein was smaller than that of alpha 1-antitrypsin in the latter. It is tempting to consider that human endodermal sinus tumors simulate the human yolk sac functionally, but the pattern of protein synthesis may differ from case to case.

摘要

据说人类卵黄囊不仅能合成甲胎蛋白，还能合成其他血清蛋白，即白蛋白、前白蛋白、α1-抗胰蛋白酶和转铁蛋白。将两例内胚窦瘤（卵黄囊瘤）成功移植到无胸腺裸鼠体内。通过电免疫扩散和放射免疫测定法定量测定裸鼠血清和肿瘤提取物中这些人类血清蛋白的浓度。在一例中检测到甲胎蛋白和白蛋白，在另一例中检测到α1-抗胰蛋白酶和甲胎蛋白。在前一例中，合成的甲胎蛋白量大于白蛋白量，而在后一例中，甲胎蛋白量小于α1-抗胰蛋白酶量。人们不禁会认为人类内胚窦瘤在功能上模拟了人类卵黄囊，但蛋白质合成模式可能因病例而异。