Gerosa M A, Olivi A, Longatti P L, Teolato S, Carteri A
Surg Neurol. 1980 May;13(5):359-62.
Recent advances indicate that cyclic nucleotides and perhaps certain adrenergic metabolites might be directly involved in contact-inhibition mechanisms and tumoral cell growth. CSF levels of 3'-5' cAMP, 3'-5' cGMP, HVA, and 5-HIAA were investigated in patients with supratentorial malignant gliomas, brain stem gliomas and posterior fossa medulloblastoma. cAMP levels were slightly decreased only in medulloblastomas, whereas no significant difference was detectable in patients with supratentorial gliomas. cGMP values turned out to be significantly higher, with a very peculiar increase in the most anaplastic neoplasms. Postoperative follow-up showed a gradual decrease of cGMP values, with progressive restoring of a normal cAMP/cGMP ratio. The possible correlation of these findings with CSF levels of HVA and 5-HIAA is discussed.
近期进展表明，环核苷酸以及某些肾上腺素能代谢产物可能直接参与接触抑制机制和肿瘤细胞生长。对幕上恶性胶质瘤、脑干胶质瘤和后颅窝髓母细胞瘤患者的脑脊液中3'-5'环磷酸腺苷（cAMP）、3'-5'环磷酸鸟苷（cGMP）、高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）水平进行了研究。仅在髓母细胞瘤中cAMP水平略有下降，而幕上胶质瘤患者中未检测到显著差异。结果发现cGMP值显著升高，在最间变的肿瘤中出现非常特殊的升高。术后随访显示cGMP值逐渐下降，cAMP/cGMP比值逐渐恢复正常。讨论了这些发现与脑脊液中HVA和5-HIAA水平的可能相关性。
