眼组织血管生成活性的证明。初步报告。

The demonstration of angiogenic activity from ocular tissues. Preliminary report.

作者信息

Glaser B M, D'Amore P A, Michels R G, Brunson S K, Fenselau A H, Rice T, Patz A

出版信息

Ophthalmology. 1980 May;87(5):440-6. doi: 10.1016/s0161-6420(80)35224-x.

Abstract

Human, bovine, and rabbit retinal extracts are shown to be capable of stimulating (1) proliferation and thymidine uptake of bovine vascular endothelial cells in cultures and (2) neovascularization of the chick chorioallantoic membrane (CAM). Extracts of skeletal muscle, heart, and liver lack similar stimulatory activity. Vitreous aspirates from patients with proliferative diabetic retinopathy, in a preliminary study, were able to stimulate vascular endothelial cell thymidine uptake. Most vitreous samples from patients without intraocular neovascularization lacked similar stimulatory activity. Indirect evidence suggests the liberation of an angiogenic factor from the retina in several ocular disorders. The data contained in this report represent the first direct evidence of angiogenic activity from mammalian retina.

摘要

已证明人、牛和兔的视网膜提取物能够刺激：（1）培养中的牛血管内皮细胞增殖和摄取胸苷；（2）鸡胚绒毛尿囊膜（CAM）的血管生成。骨骼肌、心脏和肝脏的提取物缺乏类似的刺激活性。在一项初步研究中，增殖性糖尿病视网膜病变患者的玻璃体液抽吸物能够刺激血管内皮细胞摄取胸苷。大多数无眼内新生血管形成的患者的玻璃体液样本缺乏类似的刺激活性。间接证据表明，在几种眼部疾病中，视网膜会释放一种血管生成因子。本报告中的数据代表了哺乳动物视网膜血管生成活性的首个直接证据。