来自人类小肠的甘油酯水解酶及其在中性脂质降解中的可能作用。
Glycerol-ester hydrolase from human small intestine and its possible role in the degradation of neutral lipids.
作者信息
Négrel R, Serrero G, Ailhaud G, Rey J F, Delmont J
出版信息
Digestion. 1977;16(1-2):146-59. doi: 10.1159/000198065.
A glycerol-ester hydrolase has been characterized and partially purified (23-fold) from human small intestine. A pancreatic origin was excluded through the use of an immunoserum directed against human pancreatic juice, while a pharyngeal (gastric) origin was unlikely owing to the optimum pH range of activity of the gastric enzyme as compared to that of the intestinal enzyme. The glycerol-ester hydrolase is mainly active toward short- and medium-chain di- and triglycerides and toward micellar long-chain monoglycerides. A role in the absorption of neutral lipids, mainly in pathological situations, is postulated.
已从人小肠中鉴定并部分纯化（23倍）了一种甘油酯水解酶。通过使用针对人胰液的免疫血清排除了胰腺来源，而由于与肠酶相比胃酶活性的最佳pH范围，咽（胃）来源的可能性不大。该甘油酯水解酶主要对短链和中链甘油二酯和甘油三酯以及胶束状长链甘油单酯具有活性。推测其在中性脂质吸收中起作用，主要是在病理情况下。
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