Rosival L, Szokolay A, Uhnák J
Nahrung. 1980;24(4-5):359-65. doi: 10.1002/food.19800240405.
The authors describe a model for the ecotoxicological investigation of pesticide residues guided by the analysis of various links of the food chain and of human materials. It is pointed to the possibility of studying the dynamics of the exposure to human beings by analyzing gynaecological material (prenatal stage) and samples obtained at necropsy from human beings of varying age (different durations of exposure). The observations of the relative accumulation of hexachlorobenzene, beta-BHC and DDT in butter, human milk and human fat in a region with intensive cultivation revealed a considerble accumulation of hexachlorobenzene which reaches the level of DDT. The conclusion drawn from ecotoxicological studies indicates that a reduction of the tolerances of pesticide residues in raw materials for baby foods is imperative. The analyses of gynaecological material (202 samples of the available content of the uterus and 24 placental and embryonic specimens) permitted to evidence a significant difference between two regions and a specific relationship of the observed substances and their metabolites to the fat-dissolving power of the analyzed materials.
作者描述了一种在食物链各环节及人体材料分析指导下对农药残留进行生态毒理学研究的模型。指出通过分析妇科材料（产前阶段）以及从不同年龄（不同暴露时长）的人体尸检获得的样本，有可能研究人体暴露的动态情况。在一个集约化耕种地区对黄油、人乳和人体脂肪中六氯苯、β-六六六和滴滴涕的相对积累情况进行的观察显示，六氯苯有相当程度的积累，其含量达到了滴滴涕的水平。生态毒理学研究得出的结论表明，必须降低婴儿食品原料中农药残留的耐受量。对妇科材料（202份子宫内现有物质样本以及24份胎盘和胚胎标本）的分析能够证明两个地区之间存在显著差异，以及所观察到的物质及其代谢物与被分析材料的脂肪溶解能力之间存在特定关系。
