Maru G B, Bhide S V
Arzneimittelforschung. 1980;30(7):1115-9.
Effect of isoniazid on nucleic acid biosynthesis was studied in Swiss mice. It was observed that i.p. injection of isoniazid stimulated activities of nuclease. Isoniazid also inhibits RNA biosynthesis in lung and liver tissue of 3-weeks old mice but has no inhibitory effect on the same in 6 weeks old mice. It inhibits DNA biosynthesis in lung tissue of 3- and 6-week old mice. With the decrease in nucleic acid biosynthesis and increased activities of nucleases the nucleotide pool is increased. I.p. injection of ammonium chloride produces inhibition of nucleic acid biosynthesis to a similar extent. Administration of amino acids L-arginine or L-Na-glutamate or of vitamins pyridoxine or folic acid along with isoniazid prevents the inhibitory effect of isoniazid on nucleic acid biosynthesis.
在瑞士小鼠中研究了异烟肼对核酸生物合成的影响。观察到腹腔注射异烟肼可刺激核酸酶的活性。异烟肼还抑制3周龄小鼠肺和肝组织中的RNA生物合成，但对6周龄小鼠的RNA生物合成没有抑制作用。它抑制3周龄和6周龄小鼠肺组织中的DNA生物合成。随着核酸生物合成的减少和核酸酶活性的增加，核苷酸池增加。腹腔注射氯化铵对核酸生物合成产生类似程度的抑制作用。与异烟肼一起给予氨基酸L-精氨酸或L-谷氨酸钠或维生素吡哆醇或叶酸可防止异烟肼对核酸生物合成的抑制作用。
