Turakulov Ia Kh, Khalikov S K, Rakhimov M, Sorokin V M
Vopr Med Khim. 1976 Jul-Aug;22(4):462-5.
Cobra poison at a dose of 4 microng/kg of body weight intensified the 3H-thimidine incorporation into DNA of mice liver tissue; 20-40 microng/kg of the poison inhibited the incorporation. Single intraperitoneal administration of high doses of cobra poison (50-150 microng/kg) decreased the incorporation of 14C-thimidine into DNA 1.2-1.9-fold. Little doses of the poison increased the incorporation of 14C-hydrolysate of Chlorella protein into proteins of liver cells and the high doses inhibited this process. Microdoses of cobra poison caused a distinct increase in weight of experimental mice.
剂量为4微克/千克体重的眼镜蛇毒增强了3H-胸腺嘧啶核苷掺入小鼠肝脏组织DNA的能力；20 - 40微克/千克的该毒素则抑制这种掺入。单次腹腔注射高剂量眼镜蛇毒（50 - 150微克/千克）使14C-胸腺嘧啶核苷掺入DNA的量降低了1.2 - 1.9倍。小剂量的该毒素增加了小球藻蛋白的14C-水解产物掺入肝细胞蛋白质的量，而高剂量则抑制这一过程。微量的眼镜蛇毒使实验小鼠体重明显增加。
