[Electrical and cholinoreceptive properties of muscle fiber membranes following blockade of axoplasmic transport by colchicine].

The electrical properties and acetylcholine sensitivity in frog sartorius muscle fibres were investigated after denervation and after single application of colchicine to the nerve. Similar changes followed both kinds of the nerve injury. No changes developed in the contralateral sartorius muscle. The injection of colchicine into the lymphatic sac of the frog induced extrasynaptic acetylcholine sensitivity but did not change the electrical properties of the membrane. The data obtained are considered as additional suggestion for the role of exoplasmatic transport of materials in the denervation changes in muscle if excitation transmission is intact.