[Comparative characteristics of electrophysiologic changes in frog muscle fibers after denervation and following blockade of axoplasmic transport].

Using anatomical denervation and a single application of colchicine the k ACh sensitivity and electric features of the membrane of the m. sartorius fibers were studied. Within 2 weeks after anatomical denervation a similar enlargement of the area sensitive to ACh occurred as well as a decrease in the MP values, in effective impedance, and in time constant of the muscular membrane. These data suggest that the postdenervation changes in the frog muscle are due mainly to cessation of the substances inflow with the fast axoplasmatic transport. Two latter parameters change at that more rapidly after colchicin which suggests a greater effect of the deficit of trophic substances transported along the axons, on the functioning muscle (colchicine) than on the inactive (denervation).