Mühlhauser I, Schernthaner G, Silberbauer K, Sinzinger H, Kaliman J
Artery. 1980;8(1):73-9.
The mean plasma concentrations of beta-TG and PF4 were significantly elevated in patients with diabetes mellitus, peripheral vascular disease and coronary artery disease reflecting enhanced in vivo platelet activity in some of these patients. No correlations could be observed between state of metabolic control and concentrations of platelet specific proteins in diabetic subjects. High mean beta-TG levels were noticed in diabetic patients with increasing severity of retinopathy. Raised beta-TG values decreased significantly after two weeks of treatment with dipyridamole in 10 type-I diabetics. In patients with peripheral vascular disease the WU-test, but not the ADP- or collagen induced platelet aggregation was significantly different between patients and controls, but there were no correlations between the mentioned platelet function tests.
糖尿病、外周血管疾病和冠状动脉疾病患者的β-血小板球蛋白（beta-TG）和血小板第4因子（PF4）的平均血浆浓度显著升高，这反映出其中一些患者体内血小板活性增强。在糖尿病患者中，未观察到代谢控制状态与血小板特异性蛋白浓度之间存在相关性。视网膜病变严重程度增加的糖尿病患者中，β-血小板球蛋白平均水平较高。10例I型糖尿病患者接受双嘧达莫治疗两周后，升高的β-血小板球蛋白值显著下降。在外周血管疾病患者中，患者与对照组之间的吴氏试验（WU-test）有显著差异，但二磷酸腺苷（ADP）或胶原诱导的血小板聚集无显著差异，且上述血小板功能试验之间无相关性。
