Chernukh A M, Oeme P, Gomazkov O A
Biull Eksp Biol Med. 1980 Sep;90(9):259-60.
The effective doses of substance P, bradykinin and prostaglandin E1 that induced depressor responses in rats and rabbits were compared. On molar conversion substance P showed the most pronounced activity. There was an essential difference in doses that evoked standard responses in rabbits (the preparations were administered into the right or left heart ventricle). For bradykinin the dose difference was fivefold and prostaglandin E1 twenty-twofold. Substance P did not undergo inactivation in the lungs.
比较了P物质、缓激肽和前列腺素E1在大鼠和兔中引起降压反应的有效剂量。按摩尔换算，P物质显示出最显著的活性。在兔中引起标准反应的剂量存在本质差异（制剂注入右心室或左心室）。缓激肽的剂量差异为5倍，前列腺素E1为22倍。P物质在肺中未发生失活。
