同型半胱氨酸诱导的局灶性和全身性实验性癫痫发作
Focal and generalized experimental seizures induced by homocysteine.
作者信息
Hammond E J, Hurd R W, Wilder B J, Thompson F J
出版信息
Electroencephalogr Clin Neurophysiol. 1980 Jul;49(1-2):184-6. doi: 10.1016/0013-4694(80)90366-1.
PMID:6159162
Abstract
Electrocorticographic and behavioral effects of parenteral injections of homocysteine in rats are described. Homocysteine activates experimental foci and produces focal seizures in experimental animals with pre-existing lesions. It produces generalized ECoG seizures and generalized convulsions in unlesioned animals in higher doses.
摘要
描述了经肠胃外注射同型半胱氨酸对大鼠的皮质脑电图及行为的影响。同型半胱氨酸可激活实验病灶，并在有预先存在损伤的实验动物中引发局灶性癫痫发作。在未受损动物中，高剂量的同型半胱氨酸会引发全身性皮质脑电图癫痫发作和全身性惊厥。
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