Bruneau N, Martineau J, Ragazzoni A, Roux S
Electroencephalogr Clin Neurophysiol. 1980 Jul;49(1-2):93-101. doi: 10.1016/0013-4694(80)90355-7.
Slow cortical potentials related to the ankle jerk and to its conditioning were studied in 40 adults while awake and during NREM sleep. A weak sound (S) was used as conditioned stimulus, while the ankle jerk, evoked either by Achilles tendon percussion (P) or by electrical stimulation of the sciatic nerve (H), served as unconditioned or 'imperative' stimulus. During waking, responses to simple stimuli (S, P, H) were mostly negative. During S-P and S-H pairs, responses to S were mainly negative, resembling the CNV, while these to P or to H became mostly positive, like the CNV resolution or the positive phase of the motor potential. During NREM sleep, responses to simple as well as to paired stimuli showed mostly a biphasic (negative-positive) morphology resembling the K complex. The conditioned slow potential changes obtained by pairing a sound with the ankle jerk therefore seem to be abolished during NREM sleep. This absence of conditioning can be related to the absence of habituation during NREM sleep. In 35% of the cases, however, positive slow waves were evoked by paired sounds during sleep. The possible significance of these phenomena is discussed.
在40名成年人清醒和非快速眼动睡眠期间，研究了与踝反射及其条件作用相关的慢皮层电位。一个微弱的声音（S）用作条件刺激，而通过跟腱叩击（P）或坐骨神经电刺激（H）诱发的踝反射用作非条件或“指令性”刺激。在清醒期间，对简单刺激（S、P、H）的反应大多为负向。在S-P和S-H配对期间，对S的反应主要为负向，类似于CNV，而对P或H的反应大多变为正向，类似于CNV消退或运动电位的正向期。在非快速眼动睡眠期间，对简单刺激以及配对刺激的反应大多呈现双相（负向-正向）形态，类似于K复合波。因此，通过将声音与踝反射配对获得的条件性慢电位变化似乎在非快速眼动睡眠期间消失。这种条件作用的缺失可能与非快速眼动睡眠期间缺乏习惯化有关。然而，在35%的病例中，睡眠期间配对声音可诱发正向慢波。讨论了这些现象的可能意义。
