Kosinetz G I, Buikova I A, Mamedowa T A
Folia Haematol Int Mag Klin Morphol Blutforsch. 1980;107(2):240-7.
In 24 patients affected with thalassaemia of various degrees of seriousness the functional condition of nuclear cells or red serie was investigated in the bone-marrow. The investigation was carried out by analyzing partial erythroblastogrammes, evaluating proliferative activity according to the 3H-thymidine marking index and determining ineffective erythropoiesis by means of nucleated PAS-positive erythroblasts. The findings reveal the degree of seriousness of the disease being directly dependent on the extent of functional disturbances in the cells of the erythropoietic system.
对24例不同严重程度的地中海贫血患者的骨髓有核细胞或红细胞系的功能状况进行了研究。通过分析部分幼红细胞象、根据3H-胸腺嘧啶核苷标记指数评估增殖活性以及借助有核PAS阳性幼红细胞确定无效红细胞生成来进行该项研究。研究结果显示，疾病的严重程度直接取决于红细胞生成系统细胞功能紊乱的程度。
