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几种特殊小鼠品系的细胞膜同种异体抗原决定簇

Cell membrane alloantigenic determinants of several unusual mouse strains.

作者信息

Morgan G M, McKenzie I F

出版信息

J Immunogenet. 1980 Oct;7(5):393-9. doi: 10.1111/j.1744-313x.1980.tb00733.x.

Abstract

Several interesting and clinically important strains of Mus musculus were serotyped with alloantisera recognizing the different alleles of the Thy-1, Ly-1, Ly-2, Ly-3, Ly-4, Ly-5, Ly-6 and Ly-7 loci. The strains were the Biozzi high and low responder strains, or importance in immune responsiveness studies, and the strains BXSB, MRL and MRL--lpr/lpr--strains which spontaneously develop immune complex disease. In addition the related species Mus musculus casteneus was typed with the same reagents. The knowledge of the cell surface phenotype should prove useful in various functional studies involving these interesting strains.

摘要

用识别Thy-1、Ly-1、Ly-2、Ly-3、Ly-4、Ly-5、Ly-6和Ly-7位点不同等位基因的同种抗血清,对几种有趣且具有临床重要性的小家鼠品系进行了血清分型。这些品系包括在免疫反应性研究中具有重要意义的Biozzi高反应和低反应品系,以及自发发生免疫复合物疾病的BXSB、MRL和MRL-lpr/lpr品系。此外,还使用相同的试剂对相关物种小家鼠进行了分型。细胞表面表型的知识在涉及这些有趣品系的各种功能研究中应会证明是有用的。

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