Sieck T, Wilson D B
Immunogenetics. 1981;14(3-4):293-302. doi: 10.1007/BF00342198.
Previous studies have defined a novel, MHC-linked alloantigenic system in the rat (CT) detectable with cytotoxic T cells (CTL) generated by alloimmunization and restimulation using strain combinations thought to be RT1-compatible, for instance, Lewis and Fischer 344. CTLs generated in this way are able to lyse targets from a variety of different strains without any evidence of MHC-restricted interactions, and yet these CT determinants possess properties unlike conventional class I and class II MHC gene products. The present studies employ cold target competition assays to derive a minimal estimate of the number of different CT determinants detected with Lewis anti-Fischer 344 CTLs, the number of loci involved in their expression, and their strain distribution. The results indicate that Lewis anti-Fischer CTLs define at least four different determinants encoded by at least two different loci.
以往的研究在大鼠中定义了一种新的、与主要组织相容性复合体（MHC）相关的同种异体抗原系统（CT），该系统可通过同种免疫和使用被认为是RT1兼容的品系组合（如Lewis和Fischer 344）进行再刺激产生的细胞毒性T细胞（CTL）检测到。以这种方式产生的CTL能够裂解来自多种不同品系的靶细胞，而没有任何MHC限制性相互作用的证据，然而这些CT决定簇具有与传统的I类和II类MHC基因产物不同的特性。本研究采用冷靶竞争试验来初步估计用Lewis抗Fischer 344 CTL检测到的不同CT决定簇的数量、参与其表达的基因座数量及其品系分布。结果表明，Lewis抗Fischer CTL定义了至少四个由至少两个不同基因座编码的不同决定簇。
