Watts C
Neurosurgery. 1977 Jul-Aug;1(1):2-5. doi: 10.1227/00006123-197707000-00002.
In 13,700 patients who received one or more lumbar disc injections of chymopapain, 401 complications, adverse reactions, and delayed untoward events were recorded, including eight deaths. The deaths were secondary to anaphylaxis, pulmonary embolism, discitis with subacute bacterial endocarditis, ruptured abdominal aortic aneurysms (two patients), encephalitis (of unknown etiology), and myocardial infarction. Of these, the deaths secondary to anaphylaxis and discitis with subacute bacterial endocarditis can be attributed directly to the procedure of chemonucleolysis.
在13700例接受过一次或多次木瓜凝乳蛋白酶腰椎间盘注射的患者中，记录到401例并发症、不良反应及延迟性不良事件，其中包括8例死亡。这些死亡分别继发于过敏反应、肺栓塞、椎间盘炎合并亚急性细菌性心内膜炎、腹主动脉瘤破裂（2例患者）、脑炎（病因不明）和心肌梗死。其中，继发于过敏反应和椎间盘炎合并亚急性细菌性心内膜炎的死亡可直接归因于化学溶核术。
