Chiuten D, Vogl S E, Kaplan B H, Greenwald E
Surg Gynecol Obstet. 1980 Nov;151(5):659-62.
Forty-six patients with advanced cancer of the head and neck, 42 of whom had failed conventional radiotherapy or surgical excision, or both, were treated on an outpatient basis with a regimen consisting of bleomycin, methotrexate and cis-diamminedichloroplatinum II. Objective responses were noted in 29 patients, with eight having apparent complete remissions. The median duration of partial response was only five months, but the median duration of complete remission was 11 months. Median survival time for nonresponders was four months, for partial responders, six months, and for complete responders, 20 months. Toxicity was acceptable. This regimen can be safely and conveniently used prior to radical excision or irradiation. The results in patients who failed to respond to prior therapy appear substantially superior to those achieved with methotrexate alone.
46例晚期头颈癌患者，其中42例既往常规放疗或手术切除失败，或两者均失败，在门诊接受了由博来霉素、甲氨蝶呤和顺二氯二氨铂II组成的治疗方案。29例患者出现客观缓解，其中8例明显完全缓解。部分缓解的中位持续时间仅为5个月，但完全缓解的中位持续时间为11个月。无反应者的中位生存时间为4个月，部分反应者为6个月，完全反应者为20个月。毒性是可接受的。该方案可在根治性切除或放疗前安全方便地使用。对先前治疗无反应的患者的结果似乎明显优于单独使用甲氨蝶呤所取得的结果。
