Effect of 5-azacytidine on DNA methylation in Ehrlich's ascites tumor cells.
作者信息
Tanaka M, Hibasami H, Nagai J, Ikeda T
出版信息
Aust J Exp Biol Med Sci. 1980 Aug;58(4):391-6. doi: 10.1038/icb.1980.39.
PMID:6159882
Abstract
5-Azacytidine inhibited in vivo DNA methylation in Ehrlich's ascites tumor cells depending upon the dose at which 5-azacytidine did not inhibit DNA synthesis significantly. This drug did not inhibit DNA methylation in vitro. The DNA methylase activity in ascitic cells decreased with the increasing dose of 5-azacytidine. Hypomethylated DNA was obtained from the 5-azacytidine treated ascitic cells.
摘要
Zotero 插件