Tougaard L, Buhl S, Poulsen H
Scand J Clin Lab Invest. 1977 Feb;37(1):27-31.
To evaluation the uniformity of the degree of mineralization in the skeleton the bone phosphorus/hydroxyproline ratio (bone P/Hypro) was determined in different localizations of ten human skeletons. Marked differences in bone P/Hypro were found between cortical bone and spongy bone. No difference was found between cortical bone from humerus, femur and cranium. But the mean value of these cortical bones was significantly higher than the mean value of the studied spongy bones. No significant correlation was found between the two bone types. Differences in bone P/Hypro were also found between different spongy bones. In pelvis the value did not differ between four spongy bone localizations but the mean value was significantly lower than for the other spongy bones (thoracal column, lumbal column and clavicle). Between these other spongy bones no difference was found in mean bone P/Hypro, and the mean of the pelvic bone localizations correlated significantly to the other spongy bones. The study demonstrates differences in the chemical composition of the human skeleton. A value of bone P/Hypro in the iliac crest can be used to estimation of bone P/Hypro in other spongy bones but not in cortical bones.
为评估骨骼矿化程度的均匀性，测定了10具人类骨骼不同部位的骨磷/羟脯氨酸比值（骨P/Hypro）。发现皮质骨和松质骨之间的骨P/Hypro存在显著差异。肱骨、股骨和颅骨的皮质骨之间未发现差异。但这些皮质骨的平均值显著高于所研究松质骨的平均值。两种骨类型之间未发现显著相关性。不同松质骨之间也发现了骨P/Hypro的差异。在骨盆中，四个松质骨部位的值没有差异，但平均值显著低于其他松质骨（胸椎、腰椎和锁骨）。在这些其他松质骨之间，骨P/Hypro的平均值未发现差异，骨盆骨部位的平均值与其他松质骨显著相关。该研究证明了人类骨骼化学成分的差异。髂嵴处的骨P/Hypro值可用于估计其他松质骨而非皮质骨的骨P/Hypro。
