Dupouey P, Lucas C V, Gomes D, Jacque C
J Neurosci Res. 1980;5(5):387-98. doi: 10.1002/jnr.490050504.
The topographical distribution of myelin basic protein (MBP) and of glial fibrillary acidic protein (GFA) have been compared in the CNS of 18-day-old normal, quaking, and jimpy mice using indirect immunofluorescence. Comparison was made in brain and spinal cord sections. MBP was strongly decreased in quaking and jimpy mice in all parts of the CNS. A pronounced gliosis was observed in jimpy mice with occurrence of numerous hypertrophied astrocytes. To a lesser extent, an astrocytic reaction was also observed in quaking CNS.
利用间接免疫荧光法，比较了18日龄正常、震颤和肌萎缩小鼠中枢神经系统中髓鞘碱性蛋白（MBP）和胶质纤维酸性蛋白（GFA）的分布情况。对脑和脊髓切片进行了比较。在震颤和肌萎缩小鼠的中枢神经系统所有部位，MBP均显著减少。在肌萎缩小鼠中观察到明显的胶质细胞增生，出现了大量肥大的星形胶质细胞。在震颤小鼠的中枢神经系统中也观察到了程度较轻的星形胶质细胞反应。
