Kroese A J
Scand J Clin Lab Invest. 1977 Feb;37(1):53-8.
In order to study the influence of muscular inactivity on reactive hyperaemia, postischaemic blood flow was measued with strain gauge plethysmography in the calf of twenty-nine patients, who had been treated with a plaster cast for a trauma of the lower limb. The contralateral leg served as a comparison. In all but two patients postischaemic maximal flow was lower in the immobilized calf. A negative correlation existed between maximal flow and the duration of immobilization. In the course of 6 weeks after removal of the cast, the difference in maximal flow between both sides became insignificant. Venous volume and venous emptying were not different in the two limbs. The effect of inactivity on reactive hyperaemic response may be explained by an effect of inactivity on the arterioles, muscle atrophy, a decrease in capillarization and in oxidative capacity of the muscle fibres. It is concluded that inactivity and atrophy of the lower limb musculature in patients with peripheral arterial disease may be a contributing factor to the low reactive hyperaemic response in the calf of such patients.
为研究肌肉不活动对反应性充血的影响，采用应变计体积描记法测量了29例因下肢创伤接受石膏固定治疗患者小腿的缺血后血流量，并以对侧腿作为对照。除2例患者外，固定侧小腿的缺血后最大血流量均低于对侧。最大血流量与固定时间呈负相关。去除石膏后的6周内，两侧最大血流量的差异变得不显著。两下肢的静脉容量和静脉排空情况无差异。不活动对反应性充血反应的影响可能是由于不活动对小动脉的作用、肌肉萎缩、毛细血管化减少以及肌纤维氧化能力下降所致。结论是，外周动脉疾病患者下肢肌肉组织的不活动和萎缩可能是此类患者小腿反应性充血反应低下的一个促成因素。
