Riabokon' O S, Piotrovskiĭ V K, Smirnova E B, Metelitsa V I, Mazur N A
Kardiologiia. 1980 Oct;20(10):40-2.
The article discusses the comparative antiarrhythmic effectiveness of trimecaine and lidocaine in patients with acute myocardial infarction in the first 24 hours of the disease. The 45 patients included in the study were separated into 3 groups: the 1st (control) group consisted of 15 patients with acute myocardial infarction who were not given antiarrhythmic or arrhythmogenic agents; the 2nd group was formed of 15 patients who from the time of admission were given trimecaine by intravenous drip at a rate of 2 mg/min for purposes of prevention after preliminary jet-injection of 80 mg of the drug; the 3rd group consisted of 15 patients given lidocaine by the same schedule. An antiarrhythmic effect was noted in 60% of group 2 patients and in 87% of group 3 patients. No antiarrhythmic effect was produced in 40% of patients treated with trimecaine and in 13% of those given lidocaine.
本文讨论了曲美卡因和利多卡因在急性心肌梗死发病后最初24小时患者中的抗心律失常效果比较。纳入研究的45例患者分为3组：第1组（对照组）由15例未使用抗心律失常或致心律失常药物的急性心肌梗死患者组成；第2组由15例患者组成，从入院时起以2mg/min的速率静脉滴注曲美卡因，在初步静脉推注80mg该药物后用于预防；第3组由15例按相同方案给予利多卡因的患者组成。第2组60%的患者和第3组87%的患者出现了抗心律失常效果。使用曲美卡因治疗的患者中有40%未产生抗心律失常效果，给予利多卡因的患者中有13%未产生抗心律失常效果。
