Hellgren M, Olsson P, Thulin L
Scand J Clin Lab Invest. 1977 Feb;37(1):77-84.
The acute response of the hepatic circulation to thrombinaemia and endotoxinaemia were investigated in the anaesthetized dog. Small amounts of thrombin were infused into the hepatic artery and portal vein. The effects of thrombin were compared to those of minor amounts of portally infused endotoxin. Portal pressure increased significantly following portal infusion of thrombin and endotoxin. Both substances decreased the blood flow markedly in the hepatic artery, while that in the superior mesenteric artery and portal vein decreased only slightly. Heparin and polyphlorethin phosphate (PPP) abolished all effects of thrombin. Bradykinin infused simultaneously inhibited only the effect on the hepatic artery. Vasoactive intestinal peptide, which has the same vasodilatory effect in the liver, did not. It is believed that thrombin and perhaps endotoxin exert a vasoconstrictive effect mediated by products released from platelets.
在麻醉犬身上研究了肝循环对血栓血症和内毒素血症的急性反应。将少量凝血酶注入肝动脉和门静脉。将凝血酶的作用与少量经门静脉注入内毒素的作用进行比较。门静脉注入凝血酶和内毒素后，门静脉压力显著升高。两种物质均使肝动脉血流量显著减少，而肠系膜上动脉和门静脉血流量仅略有减少。肝素和聚磷菌醇（PPP）消除了凝血酶的所有作用。同时注入的缓激肽仅抑制对肝动脉的作用。在肝脏中具有相同血管舒张作用的血管活性肠肽则没有这种作用。据信，凝血酶以及可能还有内毒素通过血小板释放的产物发挥血管收缩作用。
