Knepel W, Meyer D K
J Cardiovasc Pharmacol. 1980 Nov-Dec;2(6):815-24. doi: 10.1097/00005344-198011000-00010.
We examined whether the activation of the renin-angiotensin system after intramuscular isoprenaline injection contributes to the simultaneous increase in vasopressin release. Plasma concentrations of vasopressin and angiotensin II were measured in conscious rats using specific radioimmunoassays. Intravenous infusions of angiotensin II caused a dose-dependent increase in vasopressin release. Intravenous infusions of the angiotensin II antagonist saralasin did not diminish the isoprenaline-induced vasopressin release. However, the curve relating the isoprenaline-induced decrease in blood pressure and the concomitant increase in vasopressin levels was shifted to the right and no longer linear in saralasin-treated rats. Nephrectomy diminished the vasopressin release caused by isoprenaline when compared to sham-operation. The correlation between the decrease in blood pressure and the simultaneous vasopressin release was changed in a strikingly similar manner by nephrectomy and by saralasin infusions. It may be concluded that small doses of isoprenaline, which cause only minor decreases in blood pressure, induce vasopressin release via the renin-angiotensin system. However, the contribution of this system to vasopressin release declines as hypotension becomes more severe.
我们研究了肌肉注射异丙肾上腺素后肾素 - 血管紧张素系统的激活是否会导致血管加压素释放同时增加。使用特异性放射免疫分析法测定清醒大鼠血浆中血管加压素和血管紧张素II的浓度。静脉输注血管紧张素II导致血管加压素释放呈剂量依赖性增加。静脉输注血管紧张素II拮抗剂沙拉新并未减少异丙肾上腺素诱导的血管加压素释放。然而，在接受沙拉新治疗的大鼠中，异丙肾上腺素诱导的血压下降与血管加压素水平同时升高之间的曲线向右移动且不再呈线性。与假手术相比，肾切除术减少了异丙肾上腺素引起的血管加压素释放。肾切除术和沙拉新输注以非常相似的方式改变了血压下降与同时发生的血管加压素释放之间的相关性。可以得出结论，小剂量的异丙肾上腺素仅引起轻微的血压下降，通过肾素 - 血管紧张素系统诱导血管加压素释放。然而，随着低血压变得更加严重，该系统对血管加压素释放的贡献会下降。
