Levy R L, Chiarillo S
Oncology. 1980;37(5):316-7. doi: 10.1159/000225462.
This is a case report of hyperpyrexia, shock and death following initial injection of low-dose bleomycin (7.5 units) for a poorly differentiated metastatic carcinoma. Premedication with high-dose dexamethasone and acetaminophen did not abort the reaction. A review of the literature uncovered one nearly fatal reaction to a test dose of 1 unit of bleomycin All previously reported fatal cases were in patients with lymphoma who had received an initial dose of at least 25 units/m2. Since the 'safe' test dose of bleomycin is not known, test doses of 1 unit or lower should be routinely used; the effect of premedication is also unclear.
这是一例关于低剂量博来霉素（7.5单位）初次注射用于低分化转移性癌后出现高热、休克及死亡的病例报告。大剂量地塞米松和对乙酰氨基酚预处理未能阻止该反应。文献回顾发现有一例对1单位博来霉素试验剂量出现的近乎致命的反应。所有先前报道的致命病例均为淋巴瘤患者，其初始剂量至少为25单位/m²。由于博来霉素的“安全”试验剂量尚不清楚，应常规使用1单位或更低的试验剂量；预处理的效果也不明确。
