Levrat R, Dano P, Joliot A Y, Dechaud H, Durand D V
Nouv Presse Med. 1980 Oct 18;9(38):2811-3.
Four members of the same family (2 male and 2 female) with normal thyroid function were found to have decreased total T3 and total T4, elevated response to the T3 test and low free thyroxin index. Such biological changes result from a deficiency in carrier protein and should be distinguished from nearly similar abnormalities observed in low T3 syndrome and hypothyroidism. Whilst gonosomal transmission through the X chromosome of thyroxin-binding protein deficiency seems well established, our findings show that another mechanism, i.e. dominant autosomal heredity, is practically certain.
同一个家庭的四名成员（2名男性和2名女性）甲状腺功能正常，但总T3和总T4降低，T3试验反应升高，游离甲状腺素指数低。这些生物学变化是由于载体蛋白缺乏所致，应与低T3综合征和甲状腺功能减退中观察到的几乎相似的异常情况相区分。虽然甲状腺素结合蛋白缺乏通过X染色体的性染色体传递似乎已得到充分证实，但我们的研究结果表明，另一种机制，即常染色体显性遗传，几乎可以确定。
