Greenspon A J, Schaal S F
Pacing Clin Electrophysiol. 1980 Sep;3(5):600-4. doi: 10.1111/j.1540-8159.1980.tb05280.x.
The mitral valve prolapse syndrome is associated with a variety of atrial and ventricular arrhythmias. A portion of these patients manifest bradyarrhythmias, which in turn, may be the cause of lightheadedness and syncope. Thie study details the clinical and electrophysiologic characteristics of seven patients with symptomatic mitral valve prolapse and AV node dysfunction. The electrophysiology study demonstrated either a prolonged AH interval or abnormal response to atrial pacing in six of seven patients. A significant proportion of these patients had abnormalities of sinus node function and distal His-Purkinje conduction in addition to AV node dysfunction. AV node dysfunction in symptomatic patients with mitral valve prolapse may be secondary to autonomic dysfunction of diffuse conduction system disease.
二尖瓣脱垂综合征与多种房性和室性心律失常相关。这些患者中有一部分表现为缓慢性心律失常，进而可能导致头晕和晕厥。本研究详细阐述了7例有症状的二尖瓣脱垂合并房室结功能障碍患者的临床和电生理特征。电生理研究显示，7例患者中有6例出现AH间期延长或对心房起搏的异常反应。除房室结功能障碍外，这些患者中有很大一部分还存在窦房结功能异常和希氏束-浦肯野纤维远端传导异常。有症状的二尖瓣脱垂患者的房室结功能障碍可能继发于弥漫性传导系统疾病的自主神经功能障碍。
