自发性高血压大鼠对中枢给予P物质的血压和心率反应增强。

Blood pressure and heart rate responses to centrally administered substance P are increased in spontaneously hypertensive rats.

Unger T, Rockhold R W, Yukimura T, Rettig R, Ganten D

Clin Sci (Lond). 1980 Dec;59 Suppl 6:299s-302s. doi: 10.1042/cs059299s.

Abstract

The cardiovascular effects after intracerebroventricular injections of substance P were investigated in normotensive Wistar-Kyoto and in spontaneously hypertensive rats. 2. Substance P increased blood pressor in both rat strains. Wistar-Kyoto rats responded with moderate, dose-dependent blood pressure increases, and heart rate decreased; spontaneously hypertensive rats showed two- to three-fold increased pressor effects and, concomitantly, marked heart rate increases to intracerebroventricular injections of substance P. 3. Sino-aortic baroreceptor denervation rendered Wistar-Kyoto rats supersensitive to intracerebroventricular substance P to a similar degree as unoperated spontaneously hypertensive rats. Sino-aortic denervation had no effect on the blood pressure responses to the peptide in spontaneously hypertensive rats. 4. The central pressure actions of substance P could be markedly attenuated by intracerebroventricular pretreatment with the derivative of gamma-aminobutyric acid, baclofen. 5. We conclude that the baroreceptor reflex is disturbed in spontaneously hypertensive rats. Substance P may contribute to the pathogenesis of hypertension. The effector pathways appear to be different from angiotensin.

摘要

研究了向正常血压的Wistar - Kyoto大鼠和自发性高血压大鼠脑室内注射P物质后的心血管效应。2. P物质在两种大鼠品系中均升高血压。Wistar - Kyoto大鼠表现出中度的、剂量依赖性的血压升高，心率下降；自发性高血压大鼠对脑室内注射P物质的升压效应增加了两到三倍，同时心率显著增加。3. 去窦主动脉压力感受器使Wistar - Kyoto大鼠对脑室内P物质的敏感性增加，程度与未手术的自发性高血压大鼠相似。去窦主动脉神经支配对自发性高血压大鼠对该肽的血压反应没有影响。4. 脑室内预先用γ-氨基丁酸衍生物巴氯芬预处理可显著减弱P物质的中枢压力作用。5. 我们得出结论，自发性高血压大鼠的压力感受器反射受到干扰。P物质可能参与高血压的发病机制。其效应途径似乎与血管紧张素不同。