Heidemann E
Klin Wochenschr. 1980 Oct 15;58(20):1117-33. doi: 10.1007/BF01477234.
Humoral Factors obviously play an important role in the maintenance of the steady state in haematopoiesis. There has been work on stimulators and inhibitors for several years. Colony-stimulating factor is the best characterized chemically and biologically. Interest in more or less cell-line-specific stimulators and inhibitors of lymphopoiesis is now growing. Various tissue extracts and cell culture supernatants have been partially purified and characterized biologically and chemically. Monocytes, producing stimulators and inhibitors, have a central function in the regulation of cell proliferation in haematopoiesis. Experiments performed in vitro can help better to understand data so far difficult to explain regarding patients with disturbed haematopoiesis. The in vivo relevance of these experiments, however, remains unclear.
体液因子显然在维持造血稳态中发挥着重要作用。关于刺激物和抑制剂的研究已经开展了数年。集落刺激因子在化学和生物学方面的特征最为明确。目前，人们对淋巴细胞生成中或多或少具有细胞系特异性的刺激物和抑制剂的兴趣与日俱增。各种组织提取物和细胞培养上清液已得到部分纯化，并进行了生物学和化学特性分析。产生刺激物和抑制剂的单核细胞在造血过程中细胞增殖的调节中具有核心作用。体外实验有助于更好地理解迄今为止难以解释的造血功能紊乱患者的数据。然而，这些实验在体内的相关性仍不明确。
