[Humoral factors in the regulation of cell proliferation in haematopoiesis. I. Granulopoiesis and lymphopoiesis (author's transl)].

Humoral Factors obviously play an important role in the maintenance of the steady state in haematopoiesis. There has been work on stimulators and inhibitors for several years. Colony-stimulating factor is the best characterized chemically and biologically. Interest in more or less cell-line-specific stimulators and inhibitors of lymphopoiesis is now growing. Various tissue extracts and cell culture supernatants have been partially purified and characterized biologically and chemically. Monocytes, producing stimulators and inhibitors, have a central function in the regulation of cell proliferation in haematopoiesis. Experiments performed in vitro can help better to understand data so far difficult to explain regarding patients with disturbed haematopoiesis. The in vivo relevance of these experiments, however, remains unclear.