Subretinal neovascularization after argon laser photocoagulation.

An investigation has been conducted to test different theories relating to the pathogenesis of the disciform response. Considered an important first step in this systematic study, a reproducible model of subretinal neovascularization in an experimental primate model has been developed. The following report describes the methodology, clinical appearances, and results including histopathologic and electron microscopic correlation. This experimental model has served as a useful mechanism for testing the roles of breaks in Bruch's membrane, ischemia, hemorrhage, the inflammatory response, and position in relation to the center of the vascular free zone as important factors in the development and evolution of subretinal neovascularization.