乳腺癌患者的血清糖蛋白激素α亚基、激素受体与疾病分期
Serum glycoprotein hormone alpha subunit, hormone receptors and disease stage in patients with breast cancer.
作者信息
MacFarlane I A, Barnes D, Howat J M, Swindell R, Durning P, Beardwell C G, Bush H, Sellwood R A
出版信息
Br J Cancer. 1980 Nov;42(5):645-50. doi: 10.1038/bjc.1980.297.
The concentration of the common alpha subunit of the glycoprotein hormones was high in the serum of 21/56 (38%) of premenopausal patients and 22/106 (21%) of postmenopausal patients with primary breast cancer, at the time of presentation. 7/59 (12%) of patients with benign disease also had high alpha subunit levels. Tumour cytosol oestrogen and progesterone receptor status was determined in 80% of the patients with cancer, and there was a trend towards higher alpha levels in patients without receptors, but this was not statistically significant. In the premenopausal patients with cancer there was a significant correlation between alpha subunit level and disease stage, R = 0.47, P = 0.0001, but not in the postmenopausal patients. In view of the correlation with disease stage, high levels of alpha subunit in premenopausal patients with breast cancer at presentation with the primary tumour may indicate poor prognosis.
在初诊时，21/56（38%）的绝经前原发性乳腺癌患者和22/106（21%）的绝经后原发性乳腺癌患者血清中糖蛋白激素共同α亚基浓度较高。7/59（12%）的良性疾病患者α亚基水平也较高。80%的癌症患者测定了肿瘤细胞溶质雌激素和孕激素受体状态，无受体患者的α水平有升高趋势，但无统计学意义。在绝经前癌症患者中，α亚基水平与疾病分期显著相关，R = 0.47，P = 0.0001，但绝经后患者并非如此。鉴于与疾病分期的相关性，绝经前原发性乳腺癌初诊时α亚基水平高可能预示预后不良。
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