Krishnamoorthy G, Govindarajulu P, Ramalingam V
Department of Endocrinology, P.G. Institute of Basic Medical Sciences, Madras, India.
Neoplasma. 1989;36(2):221-31.
Different serum hormones were studied in patients with benign breast diseases and breast carcinoma in respect of different phases of the menstrual cycle, as well as in postmenopausal women. In premenopausal breast carcinoma subjects 10% showed elevated serum estradiol alone, 7% showed elevated serum prolactin alone, and 12% subjects exhibited elevated levels of both serum estradiol and prolactin. Similarly, in postmenopausal breast carcinoma subjects 12% showed elevated serum estradiol alone, 10% showed elevated serum prolactin alone, and 22% exhibited elevated level of both serum estradiol and prolactin. On the other hand, in patients with benign breast disease only 5 showed an elevated level of prolactin alone. More than 50% of premenopausal women with carcinoma of the breast had low level of serum progesterone during the luteal phase as compared to normal subjects. No variations in serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were evident between normal subjects and women with breast carcinoma or benign breast disease. The increased level of serum estradiol and prolactin may be useful in the diagnosis of human breast cancer.
我们研究了患有良性乳腺疾病和乳腺癌的患者在月经周期不同阶段以及绝经后女性体内不同血清激素的情况。在绝经前乳腺癌患者中，10%仅血清雌二醇水平升高，7%仅血清催乳素水平升高，12%的患者血清雌二醇和催乳素水平均升高。同样，在绝经后乳腺癌患者中，12%仅血清雌二醇水平升高，10%仅血清催乳素水平升高，22%的患者血清雌二醇和催乳素水平均升高。另一方面，在患有良性乳腺疾病的患者中，只有5例仅催乳素水平升高。与正常受试者相比，超过50%的绝经前乳腺癌女性在黄体期血清孕酮水平较低。正常受试者与患有乳腺癌或良性乳腺疾病的女性之间，血清促卵泡生成素（FSH）和促黄体生成素（LH）没有明显差异。血清雌二醇和催乳素水平的升高可能有助于诊断人类乳腺癌。
