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[Repair of bleomycin-induced damage to Escherichia coli DNA. II. Participation of inducible processes].

作者信息

Dzhataev S A, Tanirbergenov T B, Tarasov V A

出版信息

Genetika. 1980;16(10):1816-24.

PMID:6161859
Abstract

The role of inducible cell functions in repair and mutagenesis after bleomycin-induced DNA damages was studied in Escherichia coli. Influence on these processes of some rec genes as well as sbcB, the structural gene for exonuclease I, was investigated. The data obtained suggest that this enzyme plays a negative role in the repair of DNA damaged by bleomycin. The hypersensitivity of recA mutant to bleomycin and recAlexA-dependence of bleomycin-induced mutagenesis do not suggest any principal differences between UV-induced pyrimidine dimers and apyrimidinic sites in the case of post-replication repair.

摘要

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