Cunningham J, McCullagh P
Immunology. 1981 Jan;42(1):91-8.
Lymphocytes reactive against cultured cerebellar cells were collected from rats that had been sensitized against a variety of preparations. While cells with in vitro reactivity were invariably present in lymph from rats which were to develop encephalomyelitis, the reverse did not apply. Challenge with either neural or non-neural allogeneic tissue sensitized effectively against allogeneic neural tissue. Challenge of homograft-tolerant rats with either syngeneic or tolerated allogeneic spinal cord sensitized against neural tissues of tolerated strain.
从对多种制剂致敏的大鼠中收集对培养的小脑细胞有反应的淋巴细胞。虽然在即将发生脑脊髓炎的大鼠的淋巴中总是存在具有体外反应性的细胞，但反之则不成立。用神经或非神经同种异体组织进行攻击可有效致敏以对抗同种异体神经组织。用同基因或耐受的同种异体脊髓对同种异体移植耐受的大鼠进行攻击，可使其对耐受品系的神经组织致敏。
