Dowling J E, Watling K J
J Neurochem. 1981 Feb;36(2):569-79. doi: 10.1111/j.1471-4159.1981.tb01629.x.
The ability of dopamine, dopamine agonists, other proposed retinal neurotransmitters, depolarizing agents and light to stimulate adenylate cyclase activity in pieces of intact carp retina has been examined. The evidence indicates that a dopamine-sensitive adenylate cyclase is the only neurotransmitter activated adenylate cyclase in the carp retina. That is, only dopamine, or agents that activate dopamine receptors, appear to stimulate cyclic AMP synthesis in the retina. Depolarizing agents such as K+ or veratridine also increase retinal cyclic AMP levels, but apparently by releasing endogenous stores of dopamine. For example, the increase of retinal cyclic AMP levels induced by 45 mM-K+ is blocked by 5 mM-Co2+ or 100 microM-haloperidol, a dopamine antagonist. Flashing lights slightly increase cyclic AMP levels in the retina, an effect that is likewise abolished by haloperidol.
已经研究了多巴胺、多巴胺激动剂、其他假定的视网膜神经递质、去极化剂和光刺激完整鲤鱼视网膜碎片中腺苷酸环化酶活性的能力。证据表明，多巴胺敏感的腺苷酸环化酶是鲤鱼视网膜中唯一被神经递质激活的腺苷酸环化酶。也就是说，似乎只有多巴胺或激活多巴胺受体的物质能刺激视网膜中环状AMP的合成。去极化剂如K+或藜芦碱也会增加视网膜环状AMP水平，但显然是通过释放内源性多巴胺储备来实现的。例如，45 mM-K+诱导的视网膜环状AMP水平升高被5 mM-Co2+或100 microM氟哌啶醇（一种多巴胺拮抗剂）所阻断。闪烁光会使视网膜中环状AMP水平略有升高，这种效应同样会被氟哌啶醇消除。
