Carter J E, Dutcher J S, Carney D P, Klein L R, Black L A, Erhardt P W
J Pharm Sci. 1980 Dec;69(12):1439-40. doi: 10.1002/jps.2600691224.
An extraction and GLC assay procedure was developed for quantitation of procainamide hydrochloride and acecainide hydrochloride in rat feed. 4-Amino-N-[2-(dipropylamino)ethyl]benzamide hydrochloride was synthesized and utilized as an internal standard. The assay has good precision and accuracy and was used to establish the stability of acecainide hydrochloride and procainamide hydrochloride in rat feed.
开发了一种提取和气相色谱分析方法，用于定量大鼠饲料中的盐酸普鲁卡因胺和盐酸醋卡尼。合成了4-氨基-N-[2-(二丙基氨基)乙基]苯甲酰胺盐酸盐并用作内标。该分析方法具有良好的精密度和准确性，用于确定盐酸醋卡尼和盐酸普鲁卡因胺在大鼠饲料中的稳定性。
