Dover G J, Boyer S H, Pembrey M E
Science. 1981 Mar 27;211(4489):1441-4. doi: 10.1126/science.6162200.
Strong correlation of F-reticulocyte levels within sib pairs with sickle cell (SS) anemia suggests that the wide-ranging levels found in the SS population are governed by genes linked to the beta S-site. Correlations between F-cell levels in parents and F-reticulocyte levels in their children indicates that these same genes regulate F-cell production in nonanemic persons. Comparison of outcrossed and inbred SS populations suggests that relative well-being arises from homozygosity for alleles dictating high F-reticulocyte response to anemia.
镰状细胞（SS）贫血同胞对中F-网织红细胞水平的强相关性表明，SS人群中发现的广泛水平受与β-S位点相关的基因控制。父母的F细胞水平与子女的F-网织红细胞水平之间的相关性表明，这些相同的基因调节非贫血人群的F细胞生成。杂交和近亲繁殖的SS群体的比较表明，相对健康源于决定对贫血有高F-网织红细胞反应的等位基因的纯合性。
