残留胆道结石。使用新型胆固醇胆结石溶解剂卡普姆8210进行非手术治疗。

Retained biliary tract stones. Nonsurgical treatment with capmul 8210, a new cholesterol gallstone dissolution agent.

作者信息

Mack E, Patzer E M, Crummy A B, Hofmann A F, Babayan V K

出版信息

Arch Surg. 1981 Mar;116(3):341-4. doi: 10.1001/archsurg.1981.01380150059016.

DOI:10.1001/archsurg.1981.01380150059016

Abstract

The ability of Capmul 8210, a commercial solvent that predominantly consists of glyceryl 1-mono-octanoate, to dissolve retained common duct stones by direct infusion into the T-tube was tested in 20 patients with a total of 43 stones. Of 19 patients who completed their infusion, stone disappearance was observed in 15, giving a success rate of 79%. The dissolution time for a single stone averaged four days. A slight rise in serum alkaline phosphatase and amylase levels occurred in some patients, and rapidly returned to normal when treatment was concluded. Other side effects, such as nausea and vomiting epigastric discomfort, or diarrhea, occurred occasionally but were easily controlled medically. We believe that this agent is a useful adjunct in the management of postoperative choledocholithiasis in the patient with an indwelling T-tube.

摘要

对20例共有43颗结石的患者进行了测试，以检验主要由甘油单辛酸酯组成的商用溶剂Capmul 8210通过直接注入T形管来溶解留存胆总管结石的能力。在完成注入的19例患者中，15例结石消失，成功率为79%。单个结石的溶解时间平均为4天。部分患者血清碱性磷酸酶和淀粉酶水平略有升高，治疗结束后迅速恢复正常。其他副作用，如恶心、呕吐、上腹部不适或腹泻，偶尔发生，但通过药物治疗很容易控制。我们认为，这种药物对于留置T形管的患者术后胆总管结石的治疗是一种有用的辅助手段。