Roy P D, Moran D M, Bryant V, Stevenson R, Stanworth D R
Biochem J. 1980 Oct 1;191(1):233-7. doi: 10.1042/bj1910233.
Previous studies on histamine release by corticotropin peptides and melittin peptides were extended, leading to the identification of a synthetic peptide intermediate, Lys(Z)-Arg(NO2)-Arg(NO2)OMe, (I) as an active non-cytolytic histamine releaser from rat mast cells. However, significant differences in the releasing capacity of optical isomers of this compound, and of Lys-Lys-Arg-ArgOMe [methyl ester of corticotropin-(15-18)-tetrapeptide; 'basic core'] were observed, with the L-forms being markedly more active. A study of various analogues of the tripeptide compound (I) indicated that the structural basis for mast-cell triggering by such peptidic agents was highly specific. The relevance of these observations to the immunologically induced histamine-release processes is discussed.
先前关于促肾上腺皮质激素肽和蜂毒肽释放组胺的研究得到了扩展,从而鉴定出一种合成肽中间体,即Lys(Z)-Arg(NO2)-Arg(NO2)OMe,(I),它是一种从大鼠肥大细胞释放组胺的活性非溶细胞剂。然而,观察到该化合物的旋光异构体以及Lys-Lys-Arg-ArgOMe [促肾上腺皮质激素-(15-18)-四肽的甲酯;“碱性核心”] 的释放能力存在显著差异,L型明显更具活性。对三肽化合物 (I) 的各种类似物的研究表明,此类肽类试剂触发肥大细胞的结构基础具有高度特异性。讨论了这些观察结果与免疫诱导组胺释放过程的相关性。