免疫球蛋白E十肽诱导大鼠腹腔肥大细胞释放5-羟色胺。与促肾上腺皮质激素-（1-24）-肽、聚精氨酸、聚赖氨酸及抗原的比较。
Immunoglobulin E decapeptide-induced 5-hydroxytryptamine release from rat peritoneal mast cells. Comparison with corticotropin-(1-24)-peptide, polyarginine, polylysine and antigen.
作者信息
Coleman J W, Holgate S T, Church M K, Godfrey R C
出版信息
Biochem J. 1981 Sep 15;198(3):615-9. doi: 10.1042/bj1980615.
Abstract
A synthetic basic decapeptide from the C4 domain of human immunoglobulin E, corticotropin-(1-24)-peptide, polyarginine and polylysine stimulated up to 90% net release of 5-hydroxytryptamine from mast cells in rat peritoneal-cell suspensions. Concentration-response curves to all four polypeptides were parallel. Polyarginine and polylysine (EC50 congruent to 0.05 microM) were approximately 100-fold more potent than immunoglobulin E decapeptide and corticotropin-(1-24)-peptide (EC50 congruent to 5 microM). Polypeptide-induced release was complete within 5-10s. Immunoglobulin-E-decapeptide-induced 5-hydroxytryptamine release was additive to that induced by low concentrations of polyarginine, but non-additive to that induced by high concentrations of polyarginine. In contrast, release induced by antigen was additive along the whole length of the concentration-response curve to polyarginine. Benzalkonium chloride inhibited immunoglobulin-E-decapeptide- and polyarginine-induced 5-hydroxytryptamine release but enhanced release induced by immunological stimulation.
摘要
来自人免疫球蛋白E的C4结构域的合成碱性十肽、促肾上腺皮质激素-（1-24）-肽、聚精氨酸和聚赖氨酸可刺激大鼠腹膜细胞悬液中肥大细胞净释放高达90%的5-羟色胺。对所有四种多肽的浓度-反应曲线是平行的。聚精氨酸和聚赖氨酸（半数有效浓度约为0.05微摩尔）的效力比免疫球蛋白E十肽和促肾上腺皮质激素-（1-24）-肽（半数有效浓度约为5微摩尔）强约100倍。多肽诱导的释放可在5-10秒内完成。免疫球蛋白E十肽诱导的5-羟色胺释放与低浓度聚精氨酸诱导的释放具有相加性，但与高浓度聚精氨酸诱导的释放无相加性。相反，抗原诱导的释放在整个浓度-反应曲线上与聚精氨酸诱导的释放具有相加性。苯扎氯铵抑制免疫球蛋白E十肽和聚精氨酸诱导的5-羟色胺释放，但增强免疫刺激诱导的释放。
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