电刺激诱发豚鼠下丘脑释放[3H]组胺
Electrically-evoked release of [3H]-histamine from the guinea-pig hypothalamus.
作者信息
Biggs M J, Johnson E S
出版信息
Br J Pharmacol. 1980 Dec;70(4):555-60. doi: 10.1111/j.1476-5381.1980.tb09774.x.
Abstract
1 [3H]-histamine was taken up by slices of guinea-pig hypothalamus against a concentration gradient. 2 Electrical field stimulation of the superfused slices resulted in an increased efflux of radioactivity, the major part of which was shown to be associated with histamine by paper chromatography. 3 The evoked release of histamine was dependent on calcium ions in the superfusate and was increased by 56% when the frequency of stimulation was doubled from 5 to 10 Hz.
摘要
- [3H]-组胺能逆浓度梯度被豚鼠下丘脑切片摄取。2. 对灌流切片进行电场刺激会导致放射性外流增加，通过纸色谱法显示，其中大部分与组胺有关。3. 组胺的诱发释放依赖于灌流液中的钙离子，当刺激频率从5赫兹增加到10赫兹时，组胺的诱发释放增加了56%。
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