Wollman E E, Lepage V, Delima M, Fradelizi D, Degos L, Dausset J
C R Seances Acad Sci D. 1980 Nov 3;291(9):757-61.
By studying serologically the appearance of HLA-DR determinants on T lymphocytes activated by a mixed lymphocyte culture, we have been able to demonstrate the existence of a new class of antigenic determinants distinct from classical HLA-DR antigens. Indeed, some monospecific anti-DR sera were cytotoxic from some alloactivated T cells, though not directed against their HLA-DR specificity. The absorption of these anti-sera on B lymphocytes bearing the HLA-DR antigen against which they were directed, did not remove their reactivity on alloactivated T lymphocytes. The absorption of the same anti-sera on activated T lymphocytes did not affect their anti-DR reactivity. This study shows the existence of new antigenic determinants expressed by T lymphocytes during their activation: alloactivated T lymphocyte antigens (AATL).
通过血清学研究混合淋巴细胞培养激活的T淋巴细胞上HLA - DR决定簇的出现情况，我们得以证明存在一类不同于经典HLA - DR抗原的新型抗原决定簇。实际上，一些单特异性抗DR血清对某些同种异体激活的T细胞具有细胞毒性，尽管并非针对其HLA - DR特异性。这些抗血清在携带其针对的HLA - DR抗原的B淋巴细胞上进行吸收，并未消除它们对同种异体激活的T淋巴细胞的反应性。相同抗血清在激活的T淋巴细胞上进行吸收，也不影响其抗DR反应性。这项研究表明T淋巴细胞在激活过程中表达新的抗原决定簇：同种异体激活的T淋巴细胞抗原（AATL）。
