老年人中N-乙酰普鲁卡因胺的动力学

N-Acetyl-procainamide kinetics in the elderly.

作者信息

Galeazzi R L, Omar-Amberg C, Karlaganis G

出版信息

Clin Pharmacol Ther. 1981 Apr;29(4):440-6. doi: 10.1038/clpt.1981.61.

DOI:10.1038/clpt.1981.61

Abstract

Plasma and saliva N-acetyl-procainamide (NAPA) concentrations were measured by high-power liquid chromatography (HPLC) after intravenous infusion of 750 mg to 14 elderly patients (x age = 69 yr). The plasma NAPA disappearance curve can best be described by a two-compartment body model. Mean total body clearance was 10.6 1/hr, Vdss 125.8 1, and terminal half-life (t 1/2) 8.8 hr. A nonrenal clearance of 2.72 1/hr was calculated, that is, 19% of the expected total body clearance with normal kidney function. Saliva concentrations show huge inter- and intraindividual variability and are probably not usable for NAPA monitoring in older patients.

摘要

对14名老年患者（平均年龄69岁）静脉输注750毫克后，采用高效液相色谱法（HPLC）测定血浆和唾液中N - 乙酰普鲁卡因胺（NAPA）的浓度。血浆NAPA消除曲线最适合用二室模型来描述。平均总体清除率为10.6升/小时，稳态分布容积为125.8升，终末半衰期（t1/2）为8.8小时。计算得出非肾清除率为2.72升/小时，即正常肾功能预期总体清除率的19%。唾液浓度在个体间和个体内存在巨大差异，可能不适用于老年患者的NAPA监测。