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本文引用的文献

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Acetylornithinase of Escherichia coli: partial purification and some properties.大肠杆菌的乙酰鸟氨酸酶：部分纯化及某些性质
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2
Adjacent effect on suppression efficiency. II. Study on ochre and amber mutants of T4 phage lysozyme.抑制效率的相邻效应。II. T4噬菌体溶菌酶赭石型和琥珀型突变体的研究。
Mol Gen Genet. 1970;106(3):208-12. doi: 10.1007/BF00340380.
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Nonsense codons and polarity in the tryptophan operon.色氨酸操纵子中的无义密码子与极性
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4
Polarity and enzyme functions in mutants of the first three genes of the tryptophan operon of Escherichia coli.大肠杆菌色氨酸操纵子前三个基因的突变体中的极性和酶功能。
Genetics. 1971 Dec;69(4):409-33. doi: 10.1093/genetics/69.4.409.
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Tryptophan biosynthesis in Escherichia coli. Genetic determination of the proteins involved.大肠杆菌中的色氨酸生物合成。相关蛋白质的遗传学测定。
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Inhibition by kasugamycin of initiation complex formation on 30S ribosomes.春日霉素对30S核糖体上起始复合物形成的抑制作用。
Biochem Biophys Res Commun. 1971 Apr 2;43(1):196-9. doi: 10.1016/s0006-291x(71)80106-7.
7
Transcription of the tryptophan operon in polarity mutants of Escherichia coli. II. Evidence for normal production of tryp-mRNA molecules and for premature termination of transcription.大肠杆菌色氨酸操纵子在极性突变体中的转录。II. 色氨酸mRNA分子正常产生及转录提前终止的证据。
J Mol Biol. 1967 Aug 28;28(1):25-35. doi: 10.1016/s0022-2836(67)80074-3.
8
Regulated in vitro synthesis of Escherichia coli tryptophan operon messenger ribonucleic acid and enzymes.大肠杆菌色氨酸操纵子信使核糖核酸和酶的体外合成调控
J Biol Chem. 1974 Jan 25;249(2):465-75.
9
An intercistronic region and ribosome-binding site in bacterial messenger RNA.细菌信使核糖核酸中的基因间区域和核糖体结合位点。
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2399-403. doi: 10.1073/pnas.72.6.2399.
10
Nucleotide sequence of the trpC-trpB intercistronic region from Salmonella typhimurium.鼠伤寒沙门氏菌trpC-trpB顺反子间区域的核苷酸序列。
J Mol Biol. 1979 May 15;130(2):135-43. doi: 10.1016/0022-2836(79)90422-4.

大肠杆菌色氨酸操纵子表达过程中的翻译偶联。

Translational coupling during expression of the tryptophan operon of Escherichia coli.

作者信息

Oppenheim D S, Yanofsky C

出版信息

Genetics. 1980 Aug;95(4):785-95. doi: 10.1093/genetics/95.4.785.

DOI:10.1093/genetics/95.4.785
PMID:6162715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1214269/
Abstract

E. coli trpE polar mutations are 10 time more polar on trpD gene expression than on downstream (trpC, B, or A) gene expression. This effects was shown to be the result of "translational coupling," in which efficient translation of trpE-trpD intercistronic punctuation region consists of overlapping stop and start codons, and the trpE and trpD gene products form a functional complex in the cell. In light observations and characteristics, several models for the mechanism of translational coupling are considered.

摘要

大肠杆菌色氨酸操纵子E基因的极性突变对色氨酸操纵子D基因表达的极性影响比对下游（色氨酸操纵子C、B或A）基因表达的极性影响大10倍。这种效应被证明是“翻译偶联”的结果，其中色氨酸操纵子E-色氨酸操纵子D基因间标点区域的有效翻译由重叠的终止密码子和起始密码子组成，并且色氨酸操纵子E和色氨酸操纵子D基因产物在细胞中形成功能复合物。根据观察结果和特征，考虑了几种翻译偶联机制的模型。