Bucher U, Zimmermann A, Coninx S, Köpp P
Folia Haematol Int Mag Klin Morphol Blutforsch. 1980;107(4):574-82.
A blastic transformation in chronic myeloic leukaemia (CML) is reported, which, on the one hand, is characterized by the "lymphoid" feature of blasts and, on the other hand, by the appearance of great lymph node swellings. The clear distinction from (secondary) malignant lymphomas may be difficult. The inclusion of such forms of blastic transformation in CML is based on cytogenetic findings. Their non-granulocytic or "lymphoid" nature emerges from their cytological behavior. The fact that these lymphoid transformations respond to vincristin and prednison emphasize that their recognition as special entities is justified. They also demonstrate that the neoplastic process in CML may not only involve myelopoietic but pluripotent stem cells as well.
据报道，慢性粒细胞白血病（CML）发生了原始细胞转化，一方面，其特征为原始细胞具有“淋巴细胞样”特征，另一方面，表现为出现明显的淋巴结肿大。与（继发性）恶性淋巴瘤进行明确区分可能较为困难。将CML中的此类原始细胞转化形式纳入其中是基于细胞遗传学研究结果。它们的非粒细胞性或“淋巴细胞样”性质源于其细胞学行为。这些淋巴细胞样转化对长春新碱和泼尼松有反应，这一事实强调了将它们识别为特殊实体是合理的。它们还表明，CML中的肿瘤形成过程可能不仅涉及骨髓造血干细胞，还涉及多能干细胞。
