Lazutin V K, Smetnev A S, Zapevalov M V, Saprygin D B, Samorukova N T
Kardiologiia. 1981 Jan;21(1):21-7.
The use of the methods of multiple (35) precordial ECG leads and serial tests for the activity of creatine phosphokinase and its MB fraction allows quantitative assessment of the dimensions of the necrotic zones. In injection of contrykal with heparin the dimensions of the myocardial infarct decreased. In early injection of these agents, the clinical and electrocardiographic findings improved more rapidly and the infarction zone was smaller. Injection of contrykal with heparin arrested the anginose attack more rapidly, corrected the peripheral symptoms of circulatory insufficiency, normalized arterial pressure and relieved the congestive phenomena in the lungs within a shorter period of time. The combined use of these agents is a pathogenetically substantiated method for the treatment of patients in the acute period of myocardial infarction for the purpose of restricting the dimensions of the ischemic damage to the myocardium.
采用多个（35个）胸前心电图导联方法以及对肌酸磷酸激酶及其MB组分活性进行系列检测，可对坏死区域的大小进行定量评估。注射抑肽酶加肝素时，心肌梗死范围缩小。早期注射这些药物时，临床和心电图表现改善更快，梗死区域更小。注射抑肽酶加肝素能更快地终止心绞痛发作，纠正循环功能不全的外周症状，使动脉血压恢复正常，并在更短时间内缓解肺部充血现象。联合使用这些药物是一种基于发病机制的合理方法，用于治疗心肌梗死急性期患者，以限制心肌缺血损伤的范围。
