免疫反应与人类白细胞干扰素的长期治疗

Immune reactions and long-term therapy with human leukocyte interferon.

作者信息

Ingimarsson S, Cantell K, Carlström G, Dalton B, Paucker K, Strander H

出版信息

Acta Med Scand. 1981;209(1-2):17-19. doi: 10.1111/j.0954-6820.1981.tb11545.x.

DOI:10.1111/j.0954-6820.1981.tb11545.x

Abstract

Twenty patients with osteosarcoma were treated with exogenous human leukocyte interferon for periods ranging from 6 to 18 months. Eleven of them remained free from detectable tumour growth during this treatment. Blood samples from all patients were tested for antibodies against interferon and against impurities in the interferon preparations. No patient developed detectable levels of neutralizing antibodies against interferon. All patients formed antibodies against contaminants in the concentrated crude interferon and the partially purified interferon preparation which had been used for treatment.

摘要

20名骨肉瘤患者接受了外源性人白细胞干扰素治疗，治疗时间为6至18个月。其中11名患者在治疗期间未出现可检测到的肿瘤生长。对所有患者的血样进行了检测，以查找抗干扰素抗体和抗干扰素制剂中杂质的抗体。没有患者产生可检测到的抗干扰素中和抗体水平。所有患者都形成了针对浓缩粗制干扰素和用于治疗的部分纯化干扰素制剂中污染物的抗体。