Leckman J F, Bowers M B, Sturges J S
Am J Psychiatry. 1981 Apr;138(4):472-7. doi: 10.1176/ajp.138.4.472.
The authors completed ratings of premorbid sexual and social adjustment and assays of the CSF homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and probenecid concentrations in 108 psychiatric patients. Among the 30 patients diagnosed as schizophrenic, poor premorbid sexual adjustment was associated with higher accumulations of HVA in the CSF. No relationship between the estimated premorbid social adjustment and CSF HVA levels was observed. These findings suggest that 1) sexual and social premorbid adjustment are partially independent variables, and 2) one of the biological correlates of sexual adjustment in schizophrenic patients may be the functional maturity of central dopamine systems.
作者完成了108名精神科患者病前性和社会适应情况的评定以及脑脊液中高香草酸（HVA）、5-羟吲哚乙酸（5-HIAA）和丙磺舒浓度的测定。在30名被诊断为精神分裂症的患者中，病前性适应不良与脑脊液中HVA的较高蓄积有关。未观察到估计的病前社会适应与脑脊液HVA水平之间存在关联。这些发现表明：1）性和社会病前适应是部分独立的变量；2）精神分裂症患者性适应的生物学相关因素之一可能是中枢多巴胺系统的功能成熟。
