Kedem J, Zurovski Y, Miller H, Battler A
Arch Int Physiol Biochim. 1980 Oct;88(4):427-36. doi: 10.3109/13813458009092914.
Acute haemodynamic consequences of coronary artery ligation were evaluated in twenty-four anaesthetized open-chest dogs, nine of which were pretreated with reserpine. The following parameters were measured before, and at 15-min intervals following ligation for at least five hours : ECG, mean arterial blood pressure, aortic blood flow, left ventricular pressure, heart rate, peripheral resistance (P.R.), end-diastolic pressure, dP/dtmax, and "internal work" (I.W. = heart rate x dP/dtmax). It was found that aortic flow was similar in control and reserpine-pretreated dogs (753 +/- 43 vs. 744 +/- 57 ml/min respectively), even though heart rate, blood pressure and other parameters were significantly higher in the control animals. Furthermore, the controls could be divided into two groups : recoverers (R) and non-recoverers (N), on the basis of late stage haemodynamic differences. The ratio of PR/IW taken within one hour of ligation was significantly higher in the R group (496 +/- 69) and reserpine group (479 +/- 30) than in the N group (242 +/- 28), and could predict course of recovery in each dog studied. It is concluded that the presence of myocardial catecholamines may be deleterious to the ischemic heart when the PR or IW are disproportionately altered.
在24只麻醉开胸犬中评估了冠状动脉结扎的急性血流动力学后果，其中9只预先用利血平处理。在结扎前以及结扎后每隔15分钟测量以下参数，至少持续5小时：心电图、平均动脉血压、主动脉血流量、左心室压力、心率、外周阻力（P.R.）、舒张末期压力、dP/dtmax以及“内功”（I.W. = 心率×dP/dtmax）。结果发现，对照犬和利血平预处理犬的主动脉血流量相似（分别为753±43与744±57 ml/分钟），尽管对照动物的心率、血压和其他参数明显更高。此外，根据后期血流动力学差异，对照组可分为两组：恢复组（R）和未恢复组（N）。结扎后一小时内测得的PR/IW比值在R组（496±69）和利血平组（479±30）中显著高于N组（242±28），并且可以预测所研究的每只犬的恢复过程。结论是，当PR或IW不成比例地改变时，心肌儿茶酚胺的存在可能对缺血心脏有害。
